One indicator of an antihypercholesterolemic candidates is that they have an inhibitory activity on 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase enzyme, subsequently the cholesterol synthesis will be inhibited. This study aimed to analyze the HMG-CoA reductase inhibitory activities of Cajanus cajan leaf, Zingiber officinale var Amarum, and Zingiber officinale var Rubrum.  C. cajan leaf, and two types of Z. officinale were extracted using maceration method with three types of solvents that are water, 70% ethanol , and 96% ethanol. All of nine types resulted extracts then were analyzed the bioactive compounds, and tested for the HMG-CoA reductase inhibitory activity using HMG-CoA reductase analysis kit (BioVision’s K588-100). It was carried out in vitro using a colorimetric microplate reader with a wavelength of 340 nm at 37°C.  The results showed the extracts contain flavonoid, tannin, saponin and steroid.  The nine extracts showed inhibitory activities on HMG-CoA reductase enzyme.  There are three extracts showed highest inhibitory activity; 70% ethanolic Z. officinale var Amarum extract (by 47.87%), aqueous Z. officinale var Rubrum extract (by 40.62%), and 70% ethanolic C. cajan leaf extract (by 39.38%). These results indicate the three extracts have medium inhibitory level of HMG-CoA reductase.   The study suggested that the three types of extracts could be used as an antihypercolesterolemic candidates for further study in order to produce such antihypercholesterolemic functional food.